Decoding Cortical Conversations: Large-Scale Neural Recording with CMOS-Mated Microwire Arrays

3rd October 2024

Timing : 11 am EST

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For a list of all talks at the NanoBio seminar Series Fall'24, see here


Understanding the complex interactions within and across cortical regions during dexterous movements remains a significant challenge in neuroscience. This presentation introduces a novel approach to large-scale neural recording using CMOS-mated microwire arrays, building upon our previous work (1,2). We have developed a brain-implantable, massive parallel microwire array integrated with a high-density CMOS-multielectrode array, enabling chronic, stable recordings of over 1,300 neurons simultaneously across sensorimotor cortices in behaving mice. This technology allows for unprecedented insights into real-time cortical dynamics during complex forelimb movements. We will discuss how this system has revealed intricate patterns of inter-cortical communication and their correlation with motor performance. Additionally, we'll explore the potential applications of this technology in advancing our understanding of neural circuit function and its implications for brain-machine interfaces. This work represents a significant step forward in our ability to decode cortical conversations at a scale and resolution previously unattainable.

1. Obaid A, Hanna ME, Wu YW, et al. (2020) Massively parallel microwire arrays integrated with CMOS chips for neural recording. Science Advances. 6(12):eaay2789.
2. A Obaid, YW Wu, M Hana, et al. (2020) Ultra-sensitive measurement of brain penetration mechanics and blood vessel rupture with microscale probes. BioRxiv



Snow
Dr. Yu-Wei Wu
Assistant Research Fellow
Institute of Molecular Biology, Academia Sinica
Taiwan
Yu-Wei Wu is an Assistant Research Fellow at the Institute of Molecular Biology, Academia Sinica in Taiwan. He obtained his Ph.D. in Neurology & Neuroscience from University College London in 2012. Dr. Wu's research focuses on unraveling the neural mechanisms of movement control, with a particular emphasis on cortico-basal ganglia interactions. His lab investigates the functional dynamics of the subthalamic nucleus (STN) and its connections with the motor cortex in both normal and Parkinsonian states. Dr. Wu has made significant contributions to large-scale neural recording techniques, developing a CMOS-mated microwire bundle brain-computer interface for chronic mapping of cortical activity. This technology enables the study of real-time sensorimotor cortex dynamics during complex behaviors. He also explores how modulation of STN activity influences motor cortical function and synaptic plasticity. Dr. Wu's multidisciplinary approach combines cutting-edge experimental techniques with computational modeling to advance our understanding of basal ganglia circuit function and motor control mechanisms.