Hybrid Mechano-Optogenetic Rehabilitation After Stroke: Advancing Towards a Neurofeedback Protocol

17th October 2024

Timing : 1 pm EST

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For a list of all talks at the NanoBio seminar Series Fall'24, see here


We will describe the dynamic neural correlates following a photothrombotic stroke procedure, analyzed using wide-field calcium imaging in a head-fixed mouse model. The evolution of neural signals in the perilesional area was studied in correlation with rehabilitation using a neuro-robotic platform, combined with an optogenetic stimulation protocol. A double transgenic animal model was developed to enable full-brain recording and optical stimulation. Additionally, a novel biosensor for detecting analytes in saliva was created to provide a molecular fingerprint of stroke, enhancing the hybrid rehabilitation protocol's translational relevance. Lastly, we will discuss perspectives on integrating digital and molecular data to establish a neurofeedback protocol aimed at improving rehabilitation outcomes.